fa Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objective</strong></p><p>  This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. </p><p> <strong>Study Design</strong></p><p>  Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated. </p><p> <strong>Results</strong></p><p>  Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P < .05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P < .05). </p><p> <strong>Conclusions</strong></p><p>  Calendula officinalis extract accelerated the healing of oral mucositis in hamsters. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p><a href="http://www.oooojournal.net/article/S2212-4403(12)01503-9/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1551&slc_lang=fa&sid=1 Nader Tanideh 10031947532846007150 10031947532846007150 No Stem Cell and Transgenic Technology Research Center and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Parisa Tavakoli 10031947532846007151 10031947532846007151 No Dental Clinic, Shiraz, Iran Mohammad aAli Saghiri 10031947532846007152 10031947532846007152 Yes Department of Dental Materials and Craniofacial Research Center, School of Dentistry, Islamic Azad University, Tehran, Iran Franklin Garcia-Godoy 10031947532846007153 10031947532846007153 No Bioscience Research Center, College of Dentistry, University of Tennessee Health Science Center, Memphis, Tennessee Dariush Amanat 10031947532846007154 10031947532846007154 No Department of Oral Medicine, School of Dental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Azadeh Andisheh Tadbir 10031947532846007155 10031947532846007155 No Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Soleiman Mohammadi Samani 10031947532846007156 10031947532846007156 No Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Amin Tamadon 10031947532846007157 10031947532846007157 No Department of Animal Health Management School of Veterinary Medicine, Shiraz University, and Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran