fa Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  The objective of this study was to investigate the histogenesis of ectomesenchymal chondromyxoid tumors (ECTs) of the tongue. </p><p> <strong>Study Design</strong></p><p>  The biochemical characteristics of a rarely occurring tumor of the tongue were analyzed by immunohistochemistry and reverse-transcriptase polymerase chain reaction (RT-PCR), and its biological properties were assessed in primary culture in serum-free media. </p><p> <strong>Results</strong></p><p>  Immunohistochemistry showed that the tumor cells were strongly positive for vimentin, S-100, and glial fibrillary acidic protein (GFAP), but negative for cytokeratin and epithelial membrane antigen. In primary cultures, the cells derived from the ECT were morphologically similar to neuronal cells and expressed Nanog, GFAP, and MAP2. RT-PCR analysis of the surgical specimen was positive for OCT3/4, Sox2, Nanog, MAP2, and CD105 mRNAs. </p><p> <strong>Conclusions</strong></p><p>  The results of the present study indicate that ECTs originate from the ectomesenchymal cells of the neural crest and are similar in their molecular and biological characteristics to undifferentiated mesenchymal stem cells. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01716-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1530&slc_lang=fa&sid=1 Yukio Yoshioka 10031947532846007027 10031947532846007027 Yes Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Ikuko Ogawa 10031947532846007028 10031947532846007028 No Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan Takaaki Tsunematsu 10031947532846007029 10031947532846007029 No Department of Oral and Maxillofacial Pathobiology, Basic Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Taishi Sakaue 10031947532846007030 10031947532846007030 No Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Sachiko Yamasaki 10031947532846007031 10031947532846007031 No Oral and Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, Japan Yasuto Fukui 10031947532846007032 10031947532846007032 No Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Yasutaka Hayashido 10031947532846007033 10031947532846007033 No Oral and Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, Japan Shigeaki Toratani 10031947532846007034 10031947532846007034 No Oral and Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, Japan Tetsuji Okamato 10031947532846007035 10031947532846007035 No Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan