fa Influence of pathologic complete response to neoadjuvant chemotherapy on long-term survival of patients with advanced head and neck squamous cell carcinoma بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objective</strong></p><p>  The aim of this study was to analyze whether pathologic complete response (PCR) to neoadjuvant chemotherapy (NAC) affected long-term survival in advanced head and neck squamous cell carcinoma (HNSCC) patients. </p><p> <strong>Materials</strong></p><p>  All patients with advanced HNSCC were previously untreated and underwent NAC followed by surgery. The 5-year overall survival, disease-free survival, local control rate, and reasons for treatment failure were analyzed. </p><p> <strong>Results</strong></p><p>  A total of 101 cases were included, and the response rate to NAC was 67.3%, including 17 patients (16.8%) who achieved PCR. The 5-year overall survival (OS) of the PCR group (82.4% histologically complete response group [HCG]) was higher than that of the pathologic incomplete responder group (45.4% histologically incomplete response group [HICG]) (P = 0.045). No statistically significant difference was noted between the two groups in terms of local recurrence and nodal recurrence, but the local control rate in HCG (88.2%) was higher than that in HICG (62.7%) (P = 0.034). </p><p> <strong>Conclusions</strong></p><p>  Achieving PCR could improve locoregional control and long-term survival in patients with advanced HNSCC. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01624-0/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1526&slc_lang=fa&sid=1 Xin-rui Zhang 10031947532846006998 10031947532846006998 Yes State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Zhi-min Liu 10031947532846006999 10031947532846006999 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Xue-kui Liu 10031947532846007000 10031947532846007000 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Fenh-hua Wang 10031947532846007001 10031947532846007001 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Quan Li 10031947532846007002 10031947532846007002 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Hao Li 10031947532846007003 10031947532846007003 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Qiu-li Li 10031947532846007004 10031947532846007004 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Zhu-ming Guo 10031947532846007005 10031947532846007005 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China Zong-yuan Zeng 10031947532846007006 10031947532846007006 No State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China