fa Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objective</strong></p><p>  Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease, yet effective therapeutic approaches are lacking. This study aimed to determine the effects of application of berberine gelatin in the treatment of minor RAS (MiRAS). </p><p> <strong>Methods</strong></p><p>  A randomized, double-blind, placebo-controlled, clinical trial was performed. The gelatin containing berberine (5 mg/g) or vehicle only was applied 4 times per day for 5 days. Clinical evaluation included pain level, size, erythema, and exudation of certain ulcers on days 1, 2, 4, and 6. </p><p> <strong>Results</strong></p><p>  A total of 84 subjects fulfilled the study without obvious side effects. Berberine gelatin treatment reduced the ulcer pain score compared with placebo gelatin (P < 0.05). Ulcer size was significantly reduced (P < 0.05) and lower erythema (P < 0.05) and exudation (P < 0.05) levels were associated with berberine treatment. </p><p> <strong>Conclusions</strong></p><p>  Berberine gelatin may be a safe and effective treatment for MiRAS. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01522-2/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1525&slc_lang=fa&sid=1 Xiao-Wen Jiang 10031947532846006991 10031947532846006991 Yes Department of Stomatology, the First People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China Yi Zhang 10031947532846006992 10031947532846006992 No Department of Neurology, the First People's Hospital of Chenzhou, Chenzhou 423000, Hunan, China Ya-Li Zhu 10031947532846006993 10031947532846006993 No Institute of Translation Medicine on University of South China, Chenzhou 423000, Hunan, China Hao Zhang 10031947532846006994 10031947532846006994 No Institute of Translation Medicine on University of South China, Chenzhou 423000, Hunan, China Kun Lu 10031947532846006995 10031947532846006995 No Institute of Translation Medicine on University of South China, Chenzhou 423000, Hunan, China Fen-Fang Li 10031947532846006996 10031947532846006996 No Institute of Translation Medicine on University of South China, Chenzhou 423000, Hunan, China Hai-Yan Peng 10031947532846006997 10031947532846006997 No Institute of Translation Medicine on University of South China, Chenzhou 423000, Hunan, China