fa Intravenous bisphosphonate–related osteonecrosis of the jaw: Long-term follow-up of 109 patients بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objective</strong></p><p>  We report long-term follow-up of patients with intravenous bisphosphonate–related osteonecrosis of the jaw (BRONJ). </p><p> <strong>Study Design</strong> </p><p> Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at Memorial Sloan-Kettering Cancer Center Dental Service. </p><p> <strong>Results</strong> </p><p> Median onset of BRONJ in months was 21 (zoledronic acid), 30 (pamidronate), and 36 (pamidronate plus zoledronic acid), with a significant difference between the pamidronate plus zoledronic acid and zoledronic acid groups (P = .01 Kruskal-Wallis). The median number of doses for BRONJ onset was significantly less with zoledronic acid (n = 18) than pamidronte plus zoledronic acid (n = 36 P = .001), but not pamidronate alone (n = 29). An association between diabetes (P = .05), decayed-missing-filled teeth (P = .02), and smoking (P = .03) and progression of BRONJ was identified through χ2 test. </p><p> <strong>Conclusions</strong></p><p> <strong> </strong>This long-term follow-up of BRONJ cases enhances the literature and contributes to the knowledge of BRONJ clinical course. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)00402-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1523&slc_lang=fa&sid=1 Amber L.Watters 10031947532846006976 10031947532846006976 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Heidi J. Hansen 10031947532846006977 10031947532846006977 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Tajiaana Williams 10031947532846006978 10031947532846006978 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Joanne F.Chou 10031947532846006979 10031947532846006979 No Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Elyn Reidel 10031947532846006980 10031947532846006980 No Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Jerry Halpern 10031947532846006981 10031947532846006981 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Steven Tunick 10031947532846006982 10031947532846006982 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York George Bohle 10031947532846006983 10031947532846006983 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Joseph M.Huryn 10031947532846006984 10031947532846006984 No Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York Cherry L.Estilo 10031947532846006985 10031947532846006985 Yes Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York University College of Dentistry, New York, New York