fa Bone regeneration with a combination of nanocrystalline hydroxyapatite silica gel, platelet-rich growth factor, and mesenchymal stem cells: a histologic study in rabbit calvaria جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Objective</strong></p><p>  This study aimed to assess NanoBone as a carrier construct for mesenchymal stem cells (MSCs) and platelet-rich growth factor (PRGF). </p><p> <strong>Study Design</strong></p><p>  In the calvarial bone of 8 mature New Zealand White male rabbits, four 8-mm defects were created. Each defect received one of the following treatments: Group 1, 0.2 mg Nano-hydroxyapatite (HA) granule + 2 mL culture medium Group 2, 0.2 mg Nano-HA + 1 mL autologous PRGF + 2 mL acellular culture medium Group 3, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs Group 4, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs + 1 mL autologous PRGF. </p><p> <strong>Result</strong></p><p>  Histomorphometric analysis at 6 and 12 weeks demonstrated significantly higher bone formation in group 4 (29.45% and 44.55%, respectively) (P < .05). Bone formation in groups 1, 2, and 3 were as follows: 11.35% and 32.53%, 29.10% and 39.74%, and 25.82% and 39.11%, respectively. </p><p> <strong>Conclusions</strong></p><p> <strong> </strong>NanoBone with MSCs and PRGF seems to be an effective combination for bone regeneration in a rabbit calvaria model. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)00121-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1520&slc_lang=fa&sid=1 Hossein Behnia 10031947532846006958 10031947532846006958 No Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti Medical University, Tehran, Islamic Republic of Iran Arash Khojasteh 10031947532846006959 10031947532846006959 Yes Dental Research Center, Shahid Beheshti Medical University, Tehran, Islamic Republic of Iran Mohammad Taghi Kiani 10031947532846006960 10031947532846006960 No Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran Ahad Khosh Zaban 10031947532846006961 10031947532846006961 No Iranian Tissue Bank Research & Preparation Center, Eye Research Center, Stem Cell Preparation Unit, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Fatemeh Mashhadi Abbas 10031947532846006962 10031947532846006962 No Oral and Maxillofacial Pathology, Shahid Beheshti Medical University, Dental Faculty, Tehran, Islamic Republic of Iran Maryam Bashtar 10031947532846006963 10031947532846006963 No Iranian Tissue Bank Research & Preparation Center, Imam Khomeini Medical Complex Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Seyede Ghazaleh Dashti 10031947532846006964 10031947532846006964 No Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran