fa Photodynamic treatment of oral lichen planus بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objectives</strong></p><p>  The aim of this study was to examine the clinical behavior and response to topical methyl 5-aminolevulinate (MAL) photodynamic therapy (PDT) of oral lichen planus and to describe the buildup and biodistribution of photoactive porphyrins in normal and lichen planus–affected oral mucosa after MAL application. </p><p> <strong>Study Design</strong></p><p>  The difference in clinical expression in 14 patients with buccal oral lichen planus was compared before and after treatment. MAL-induced photoactive porphyrins were monitored using noninvasive in situ fluorescence measurements. Microfluorometry was used to study the biodistribution. </p><p> <strong>Results</strong></p><p> <strong> </strong>The absorption and conversion of protoporphyrin IX (PpIX) in epithelial and subepithelial T cells was demonstrated in histologic sections. As a result of 1 treatment session, there was a significant improvement of oral lichen planus after 6 months (P = 0.02) and during a 4-year follow-up period. </p><p> <strong>Conclusions</strong></p><p> <strong> </strong>MAL is absorbed and converted to PpIX in T cells. Oral lichen planus treated with MAL-PDT showed lasting improvement after a single treatment. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01501-5/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1499&slc_lang=fa&sid=1 Sigrid I.Kvaal 10031947532846006839 10031947532846006839 Yes Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway Even Angell-Petersen 10031947532846006840 10031947532846006840 No Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Trand Warloe 10031947532846006841 10031947532846006841 No Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway