en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan-containing gels in early wound healing after scaling and root planing (SRP).</p><p> <strong> Methods</strong>: In this randomized clinical study, data from 34 individuals with chronic periodontitis were evaluated after full-mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis. </p><p> <strong>Results</strong>: In both groups, PD and CAL were significantly reduced (P <0.001). The changes in PD and the reduction of the number of pockets with PD ≥5 mm were significantly higher in the test group after 3 (P = 0.014 and 0.021) and 6 (P = 0.046 and 0.045) months. Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups (both P = 0.043), as were those of Campylobacter rectus in the test group only (P = 0.028). Prevotella intermedia and Porphyromonas gingivalis increased in the control group. </p><p> <strong>Conclusion</strong>: The adjunctive application of hyaluronan may have positive effects on PD reduction and may prevent recolonization by periodontopathogens. </p><hr><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120269" target="_blank"><font color="#0000ff">Full Text</font></a></p> Chronic periodontitis, hyaluronic acid, leukocyte elastase, microbiology, root planing, wound healing 0 0 http://idai.ir/browse.php?a_code=A-10-32-1328&slc_lang=en&sid=1 Sigrun Eick 10031947532846005913 10031947532846005913 No Department of Periodontology, Laboratory of Oral Microbiology, Dental School, University of Bern, Bern, Switzerland Antonio Renatus 10031947532846005914 10031947532846005914 No Department of Periodontology, University Hospital of Leipzig, Leipzig, Germany Melanie Heinicke 10031947532846005915 10031947532846005915 No Department of Periodontology, University Hospital of Leipzig, Leipzig, Germany Wolfgang Pfister 10031947532846005916 10031947532846005916 No Institute of Medical Microbiology, University Hospital of Jena, Jena, Germany Stefan-Ioan Stratul 10031947532846005917 10031947532846005917 No Center for Periodontology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania Holger Jentsch jenh@medizin.uni-leipzig.de 10031947532846005918 10031947532846005918 Yes Department of Periodontology, University Hospital of Leipzig, Leipzig, Germany