en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> The main objective of the present study is to quantify doxycycline (DOX) release from β-tricalcium phosphate (β-TCP) after EDTA root surface treatment.</p><p> <strong> Methods</strong>: Thirty systemically healthy patients with ≥1 paired contralateral interproximal intrabony defect ≥4 mm deep along with an interproximal probing depth ≥6 mm and clinical attachment level ≥4 mm were randomized into two groups. Group 1 (G1) consisted of sites treated with open flap debridement followed by placement of DOX blended with β-TCP (DOX-β-TCP), whereas group 2 (G2) sites were treated with flap surgery followed by the placement of DOX blended with β-TCP after EDTA etching of the exposed root surfaces (DOX-β-TCP + EDTA). Samples of gingival crevicular fluid (GCF) were obtained 1, 3, 7, 14, and 21 days after surgery. Quantitative measurements of DOX were taken with high-performance liquid chromatography. Clinical evaluation and follow-up for 6 months were performed. </p><p> <strong>Results:</strong> At 21 days, the DOX-β-TCP + EDTA–treated group showed a 194.7 µg/mL value. The DOX-β-TCP + EDTA–treated group retained more DOX during the periods of 3, 7, 10, 14, and 21 days than the DOX-β-TCP–treated group. Six months after therapy, DOX-β-TCP + EDTA–treated sites showed more significant clinical improvements compared to DOX-β-TCP–treated sites (P ≤ 0.05). </p><p> <strong>Conclusions</strong>: EDTA root surface etching enhances DOX availability in the GCF following its release from β-TCP as a drug carrier. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120343" target="_blank"><font color="#0000ff">Full Text</font></a></p> Beta-tricalcium phosphate, doxycycline, edetic acid, EDTA, gingival crevicular fluid, guided tissue regeneration 0 0 http://idai.ir/browse.php?a_code=A-10-32-1326&slc_lang=en&sid=1 Ahmed Y. Gamal hgamal1@perio.org 10031947532846005906 10031947532846005906 Yes Faculty of Dental Medicine, Department of Periodontology, Al-Azhar University, Cairo, Egypt Radi M. Kumper 10031947532846005907 10031947532846005907 No Faculty of Dental Medicine, Department of Periodontology, Al-Azhar University, Cairo, Egypt Abd El Reheem R. Al Gendy 10031947532846005908 10031947532846005908 No Faculty of Dental Medicine, Department of Periodontology, Al-Azhar University, Cairo, Egypt