en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> The objective of this study is to compare a candidate β-tricalcium phosphate (β-TCP) carrier technology with the absorbable collagen sponge (ACS) benchmark to support recombinant human growth/differentiation factor-5 (rhGDF-5)–stimulated periodontal wound healing/regeneration. </p><p> <strong>Methods:</strong> Routine, bilateral, critical-size (5-mm), 1-wall, intrabony periodontal defects were surgically created in the mandibular premolar region in 10 beagle dogs. Five animals received rhGDF-5/β-TCP and five animals received rhGDF-5/ACS, with a total of 20 μg rhGDF-5 per defect. The animals were euthanized for histologic and histometric analyses at 8 weeks postsurgery. </p><p> <strong>Results:</strong> Both rhGDF-5/ACS and rhGDF-5/β-TCP stimulated the formation of functionally oriented periodontal ligament, cellular mixed fiber cementum, and woven/lamellar bone. Bone regeneration (height and area) was significantly greater for the rhGDF-5/β-TCP construct than for the rhGDF-5/ACS (3.26 ± 0.30 mm versus 2.22 ± 0.82 mm, P <0.01 and 10.45 ± 2.26 mm2 versus 5.62 ± 2.39 mm2, P <0.01, respectively). Cementum formation ranged from 3.83 ± 0.73 mm to 3.03 ± 1.18 mm without significant differences between groups. Root resorption/ankylosis was not observed. </p><p> <strong>Conclusions:</strong> The β-TCP carrier technology significantly enhanced rhGDF-5–stimulated bone formation compared with the ACS benchmark in this discriminating periodontal defect model. The structural integrity of the β-TCP carrier, preventing compression while providing a framework for bone ingrowth, may account for the observed results. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120307" target="_blank"><font color="#0000ff">Full Text</font></a></p> Animal models, beta-tricalcium phophate, growth differentiation factor 5, tissue engineering 0 0 http://idai.ir/browse.php?a_code=A-10-32-1314&slc_lang=en&sid=1 Young-Taek Kim 10031947532846005844 10031947532846005844 No Department of Periodontology and Dentistry, National Health Insurance Corporation Ilsan Hospital, Seoul, Korea Ulf M.E. Wikesjö 10031947532846005845 10031947532846005845 No Laboratory for Applied Periodontal & Craniofacial Regeneration, Georgia Health Sciences University College of Dental Medicine, Augusta, GA Ui-Won Jung 10031947532846005846 10031947532846005846 No Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea Jung-Seok Lee 10031947532846005847 10031947532846005847 No Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea Tae-Gyun Kim 10031947532846005848 10031947532846005848 No Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea Chong-Kwan Kim ckkimperio@gmail.com 10031947532846005849 10031947532846005849 Yes Department of Periodontology, Research Center for Orofacial Hard Tissue Regeneration (MRC), College of Dentistry, Yonsei University