en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background</strong>: In this study, we compare the effects of enamel matrix derivative (EMD) associated with a hydroxyapatite and β-tricalcium phosphate (HA/β-TCP) implant to EMD alone and to open-flap debridement (OFD) when surgically treating 1- to 2-wall intrabony defects. <strong></strong></p><p> <strong>Methods:</strong> Thirty-four patients, exhibiting ≥3 intraosseous defects in different quadrants, were each treated by OFD, EMD, or EMD + HA/β-TCP in each defect. At baseline and 12 and 24 months, a complete clinical and radiographic examination was done. Pre-therapy and post-therapy clinical (probing depth [PD], clinical attachment level [CAL], and gingival recession [GR]) and radiographic (defect bone level [DBL] and radiographic bone gain [RBG]) parameters for the different treatments were compared. </p><p> <strong>Results:</strong> After 12 and 24 months, almost all the clinical and radiographic parameters showed significant changes from baseline within each group (P <0.001). Differences in PD, CAL, and DBL scores were also seen among the three groups at the 12- and 24-month visits (P <0.001). At 12 and 24 months after treatment, the EMD + HA/β-TCP group showed significantly greater PD reduction (4.00 ± 0.42 mm 4.25 ± 0.63 mm), CAL gain (3.47 ± 0.65 mm 3.63 ± 0.91 mm), and RBG (3.17 ± 0.69 mm 3.35 ± 0.80 mm) and less GR increase (0.56 ± 0.37 mm 0.63 ± 0.42 mm) compared with the OFD and EMD groups (P <0.05). </p><p> <strong>Conclusion:</strong> Our data support the hypothesis that the adjunct of an HA/β-TCP composite implant with EMD may improve the clinical and radiographic outcomes of the surgical treatment of unfavorable intrabony defects. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.110656" target="_blank"><font color="#0000ff">Full Text</font></a></p> Clinical trials, enamel matrix proteins, guided tissue regeneration, periodontal, periodontal diseases, transplants 0 0 http://idai.ir/browse.php?a_code=A-10-32-1275&slc_lang=en&sid=1 Dario De Leonardis 10031947532846005605 10031947532846005605 No Department of Periodontology, G. d’Annunzio University, School of Dentistry, Chieti, Italy/Private practice, Rome, Italy Michele Paolantonio mpaolantonio@unich.it 10031947532846005606 10031947532846005606 Yes Department of Periodontology, G. d’Annunzio University, School of Dentistry, Chieti, Italy