en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> Progression of diabetes-associated periodontal destruction and the roles of advanced glycation end products (AGEs) are investigated. </p><p> <strong>Methods:</strong> Diabetes was induced by streptozocotin injection, and periodontitis was induced via silk ligature placement with Porphyromonas gingivalis lipopolysaccharide injection in 64 Sprague-Dawley rats for 7 to 21 days. The quality of alveolar bone and attachment loss (AL) were measured by microcomputed tomography and histology. Destruction profiles were evaluated by histology, histochemistry, immunohistochemistry, and quantitative assessments of inflammatory cells, expression of receptors for AGEs (RAGE), tartrate-resistant acid phosphatase, and proliferating cell nuclear antigen. </p><p> <strong>Results: </strong>Without periodontitis induction, there was no obvious morphologic change in the periodontium, although slight elevations of AGEs and RAGE levels were noted in animals with diabetes. In the group with experimental periodontitis, significant periodontal bone loss was noted in animals both with and without diabetes from day 7, with more progressive bone loss in animals with diabetes during days 14 to 21. Histologically, the disruption of attachment and inflammation were observed from day 7, but subsequently subsided in animals without diabetes. A stronger and more prolonged response with significant AL was observed in animals with diabetes. Stronger inflammation, attenuated and persistent resorptive activity, and weaker proliferating potential were demonstrated by animals with diabetes. AGE deposition and RAGE expression were noted in animals without diabetes but with periodontitis, although levels were considerably elevated in the later stages in animals with diabetes. </p><p> <strong>Conclusions</strong>: Diabetes augments periodontal destruction by reducing the proliferating capability and activating resorptive activities. Presence of the AGE-RAGE axis without diabetes implies that it is involved in the regulation of inflammation. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120076" target="_blank"><font color="#0000ff">Full Text</font></a></p> Advanced glycosylation end-product receptor, diabetes mellitus, immunohistochemistry, inflammation, periodontitis, x-ray microtomography 0 0 http://idai.ir/browse.php?a_code=A-10-32-1270&slc_lang=en&sid=1 Po-Chun Chang changpc@ntu.edu.tw 10031947532846005569 10031947532846005569 Yes Faculty of Dentistry, National University of Singapore, Singapore, Singapore/School of Dentistry, National Taiwan University, Taipei, Taiwan Li-Ying Chien 10031947532846005570 10031947532846005570 No Faculty of Dentistry, National University of Singapore, Singapore, Singapore Jin Fei Yeo 10031947532846005571 10031947532846005571 No Faculty of Dentistry, National University of Singapore, Singapore, Singapore Yi-Ping Wang 10031947532846005572 10031947532846005572 No School of Dentistry, National Taiwan University, Taipei, Taiwan Min-Chun Chung 10031947532846005573 10031947532846005573 No Faculty of Dentistry, National University of Singapore, Singapore, Singapore Li Yen Chong 10031947532846005574 10031947532846005574 No Faculty of Dentistry, National University of Singapore, Singapore, Singapore Mark Yen-Ping Kuo 10031947532846005575 10031947532846005575 No School of Dentistry, National Taiwan University, Taipei, Taiwan/Department of Periodontics, National Taiwan University Hospital, Taipei, Taiwan Chun-Hao Chen 10031947532846005576 10031947532846005576 No School of Dentistry, National Taiwan University, Taipei, Taiwan/Department of Periodontics, National Taiwan University Hospital, Taipei, Taiwan Huan-Ching Chiang 10031947532846005577 10031947532846005577 No School of Dentistry, National Taiwan University, Taipei, Taiwan/Department of Periodontics, National Taiwan University Hospital, Taipei, Taiwan Benjamin N. Ng 10031947532846005578 10031947532846005578 No Faculty of Dentistry, National University of Singapore, Singapore, Singapore