en بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background and aims.</strong></p><p>  Biocompatibility of root-end filling materials is a matter of debate. The aim of this study was to compare the biocompatibility of a variety of commercial ProRoot WMTA cements and a resin-based cement (Geristore®) with different pH values of setting reaction and different aluminum contents, implanted into the subcutaneous connective tissue of rats at various time intervals.</p><p> <strong> Materials and methods.</strong></p><p>  Fifty Sprague-Dawley rats were used in this study. Polyethylene tubes were filled with Angelus WMTA, ProRoot WMTA, Bioaggregate, and Geristore. Empty control tubes were implanted into subcutaneous tissues and harvested at 7-, 14-, 28- and 60-day intervals. Tissue sections of 5 μm were stained with hematoxylin and eosin and observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells) 1, mild (inflammatory cells ≤25) 2, moderate (25–125 inflammatory cells) and 3, severe (>125 inflammatory cells). Statistical analysis was performed with Kruskal-Wallis and Mann Whitney U tests. </p><p><strong>Results.</strong></p><p> ProRoot WMTA and Angelus elicited significantly less inflammation than other materials (P< 0.05). After 7 days, however, all the materials induced significantly more inflammation than the controls (P< 0.05). Angelus-MTA group exhibited no significant differences from the Bioaggregate group (P=0.15) however, ProRoot WMTA elicited significantly less inflammation than Bioaggregate (P=0.02). Geristore induced significantly more inflammation than other groups (P< 0.05). </p><p> <strong>Conclusion.</strong> </p><p> Geristore induced an inflammatory response higher than ProRoot WMTA therefore, it is not recommended for clinical use. </p><hr><p></p><p> <strong>Source: </strong>Journal of Dental Research, Dental Clinics, Dental Prospects</p><p> <a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/480" target="_blank"><font color="#0000ff">Full Text</font></a></p> Bioaggregate, biocompatibility, endodontic cement, Geristore, mineral trioxide aggregate 0 0 http://idai.ir/browse.php?a_code=A-10-32-1054&slc_lang=en&sid=1 Mohammad Ali Saghiri 10031947532846004597 10031947532846004597 No Center for Excellence in Endodontic Materials, Professor Kamal Asgar Research Center (KARC) For Dental Materials and Devices, Tehran, Iran Nader Tanideh 10031947532846004598 10031947532846004598 No Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran Franklin Garcia-Godoy 10031947532846004599 10031947532846004599 No Bioscience Research Center, College of Dentistry, the University of Tennessee Health Science Center, Memphis, TN, USA Mehrdad Lotfi 10031947532846004600 10031947532846004600 No Research Center for Pharmaceutical Nanotechnology and Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Kasra Karamifar 10031947532846004601 10031947532846004601 No Dariush Amanat amanatd@sums.ac.ir 10031947532846004602 10031947532846004602 Yes Department of Oral Medicine, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran