en کودکان Pediatric Dentistry پژوهشي Research <p> <strong>Background and aims</strong>.</p><p>  The aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (DPC) with calcium hydroxide [Ca(OH)2] and simvastatin as pulp-capping materials in the primary human molars. </p><p> <strong>Materials and methods</strong>.</p><p>  120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. Group Ι as a control, underwent DPC with calcium hydroxide. The dental pulp in group ІІ, ІІІ and ІV were directly capped with simvastatin-based materials at concentrations of 1, 5 and 10 µM, respectively. All of the teeth were restored with stainless steel crown. After a mean period of 7.41 months teeth were extracted and processed for histological examination and categorized in terms of hard tissue formation and pulp inflammation. </p><p> <strong>Results.</strong></p><p>  Teeth in group I had statistically favorable outcomes in hard tissue formation and pulp inflammation than did the groups ІІ, ІІІ and ІV (P < 0.001). Considering three different concentrations of simvastatin, the result showed a dose dependent trend. Teeth in group ІV showed significantly lower rates of hard tissue formation and higher rates of pulp inflammation and necrosis compared to those of groups ІІ (P < 0.05). </p><p> <strong>Conclusion.</strong></p><p>  The findings of this study depicted that healing with no inflammation and hard tissue formation following statin treatment occurs with a lower rate than that with the calcium hydroxide.  </p><hr><p></p><p> <strong>Source: </strong>Journal of Dental Research, Dental Clinics, Dental Prospects</p><p><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/475" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Calcium hydroxide, direct pulp capping, simvastatin, hard tissue formation, inflammation 0 0 http://idai.ir/browse.php?a_code=A-10-32-1053&slc_lang=en&sid=1 Naser Asl Aminabadi aslaminabadi@gmail.com 10031947532846004591 10031947532846004591 Yes Department of Pediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Ensiyeh Maljaei 10031947532846004592 10031947532846004592 No Department of Pediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Leila Erfanparast 10031947532846004593 10031947532846004593 No Department of Pediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Amir Ala Eghbali 10031947532846004594 10031947532846004594 No Department of Oral Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Hamed Hmaishehkar 10031947532846004595 10031947532846004595 No 6Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Ebrahim najafpour 10031947532846004596 10031947532846004596 No Department of Pediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran