en بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background and aims.</strong></p><p>  The role of cytokines in the immunopathogenesis of oral lichen planus (OLP) has received much attention. The aim of this study was to evaluate the serum levels of TNF-α and TGF-β in patients with OLP in an Iranian population. </p><p> <strong>Materials and methods.</strong></p><p>  Thirty-two patients with OLP and 32 age-matched healthy volunteers as a control group were included in this study. Serum tests including TNF-α and TGF-β was performed in both groups. Data analysis was performed using descriptive statistics and Mann–Whitney U test using SPSS software version 16.0.<strong> </strong></p><p> <strong>Results.</strong></p><p>  The mean of TNF-α in study and control groups were 157 ± 115 pg/ml and 14 ± 10 pg/ml, respectively. The difference between the two means was statistically significant (P < 0.001). Moreover, the mean of TGF-β in study and control groups were 155 ± 26 pg/ml and 175 ± 57 pg/ml, respectively. The difference between the two means was statistically significant (P = 0.03). </p><p> <strong>Conclusion.</strong></p><p>  According to the results of the present study, there was a significant decrease in the serum levels of TGF-β and a significant increase in the serum levels of TNF-α in patients with oral lichen planus. The increase in TNF-α serum levels in patients with OLP explains the inflammatory process in the course of the disease. </p><hr><p></p><p> <strong>Source: </strong>Journal of Dental Research, Dental Clinics, Dental Prospects</p><p><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/266" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Oral lichen planus, TGF-α, TNF-β. 0 0 http://idai.ir/browse.php?a_code=A-10-32-1049&slc_lang=en&sid=1 Ali Taghavi Zenouz 10031947532846004578 10031947532846004578 No Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Firoz Pouralibaba 10031947532846004579 10031947532846004579 No Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Zohreh Babaloo 10031947532846004580 10031947532846004580 No Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Masoumeh Mehdipour 10031947532846004581 10031947532846004581 No Department of Oral Medicine, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Jamali z.jamali55@gmail.com 10031947532846004582 10031947532846004582 Yes Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran