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جشنواره سال 1392: نفرات برتر مقاله پژوهشی پریودنتولوژی

 نفرات برتر مقاله پژوهشی پریودنتولوژی

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نفر اول مقاله پژوهشی پریودنتولوژی

  Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

  


  Tahereh Sadat Jafarzadeh Kashi , Solmaz Eskandarion , Mehdi Esfandyari-Manesh , Seyyed Mahmoud Amin Marashi , Nasrin Samadi , Seyyed Mostafa Fatemi , Fatemeh Atyabi , Saeed Eshraghi ,   Rassoul Dinarvand *   

  * Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran

 

  

  Abstract  

  Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections.

  Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity.

  Results: The nanoparticles prepared in this study were spherical, with an average particle size of 85–424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%). oil/oil (5.5%) . water/oil/water (4.7%) . modified oil/water (4.1%) . nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug.

  Conclusion: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.

  Keywords: nanoparticle, PEGylation, PLGA, ion pairing, minocycline, antibacterial.  


  International Journal of Nanomedicine 2012:7 221–234

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نفر دوم مقاله پژوهشی پریودنتولوژی

Bacterial Analysis of Peri-implantitis and Chronic Periodontitis in Iranian Subjects

  


  Ahmad Reza Ebadian , Mahdi Kadkhodazadeh , Parisa Zarnegarnia , Gunnar Dahlén  


  Acta Medica Iranica, Vol. 50, No. 7 (2012)

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