Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx ® Brush in early detection of oral potentially malignant lesions and oral cancer
, Zahra Delavarian, Nooshin Mohtasham, Pegah Mosannen-Mozaffari*, Atessa Pakfetrat
Mohammad-Taghi Shakeri, Rasoul Ghafoorian-Maddah
* Assistant Professor of Oral Medicine, Dental Research Center of Mashhad Dental School,Mashhad University of Medical Sciences
Objectives: To determine diagnostic value of modified Liquid Based Brush Biopsy technique.
Study design: 26 oral premalignant and malignant lesions in 25 patients (12 females; 54.23±19.77 years and 13 males; 53.77±15.43 years) underwent Modified (Liquid Based) Brush Biopsy and scalpel biopsy simultaneously from the same area.
Results: There were 16 positive and 10 negative brush biopsy results, with no inadequate readings. Histological findings were compatible with oral leukoplakia (n=5)with dysplasia, Oral lichen planus and lichenoid reaction (n=7) (with or without dysplasia)oral squamous cell carcinoma(n=11), verrucous carcinoma (n=1) and granular cell tumors (n=2). Sensitivity, specificity, positive predictive value, negative predictive value, positive diagnostic likelihood ratio (LR+) and negative diagnostic likelihood ratio(LR-) were 88.8%,100%,100% , 80%, infinity and 0.11 respectively (no false positive results).
Conclusion: It is the first attempt to do LBC (liquid based cytology) with a specialized oral brush. Our results show that modified technique is a useful tool for screening of oral premalignant and malignant lesions.
Med Oral Patol Oral Cir Bucal. 2010 Sep 1;15 (5):671-6.