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جشنواره سال 1394: نفرات برتر مقاله پژوهشی بیماریهای دهان و فک و صورت

نفرات برتر  مقاله پژوهشی بیماریهای دهان و فک و صورت

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 نفر اول مقاله پژوهشی بیماریهای دهان و فک و صورت

A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial


Hasan Hoseinpour Jajarm, Farnaz Falaki, Majid Sanatkhani, Meysam Ahmadzadeh,Farzaneh Ahrari, Hooman Shafaee

*Department of Orthodontics and Dental Research Center,Faculty of Dentistry,Mashahd University of Medical 

Sciences,Mashahd,Iran


Abstract

Recently, photodynamic therapy (PDT) has been suggested as a new treatment option that is free from side effects for erosive-atrophic oral lichen planus (OLP). The purpose of this study was to compare the effect of toluidine blue mediated photodynamic therapy (TB-PDT) with local corticosteroids on treatment of erosive-atrophic OLP. In this randomized clinical trial, 25 patients with keratotic-atrophicerosive oral lichen planus were allocated randomly into two groups. Group 1 (experimental): topical application of toluidine blue with micropipette was applied, and after 10 min, the patients were treated with a 630-nm GaAlAs laser (power density: 10 mW/cm2) during two visits. Group 2 (control) used mouthwash diluted with dexamethasone (tab 0/5 in 5 ml water) for 5 min, and then, it was spat out, and after 30 min, the mouth was rinsed with 30 drops of nystatin 100,000 units for 5 min and again spat out. Demographic data, type, and severity of the lesions and pain were recorded before and after treatment and then at the 1-month follow-up visit. Response rate was defined based on changes in intensity of the lesions and pain. In the experimental and control groups, sign scores of changes significantly reduced after treatment respectively (p=0.021) and (p=0.002), but between the two groups, no significant difference was observed (p= 0.72). In the experimental (p=0.005) and control groups (p= 0.001), the intensity of lesions significantly reduced after treatment and there was a significant difference between the two groups (p=0.001). The mean amount of improvement in pain was significantly greater in the control group compared with the experimental group (p<0.001) (α=0.05). Our study showed that TB-PDT with laser was effective in the management of OLP.

Keywords : Corticosteroid therapy , Photodynamic therapy , Oral lichen planus


Lasers Med Sci, 9 December 2014 

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نفر دوم مقاله پژوهشی بیماریهای دهان و فک و صورت

The therapeutic effect of chamomilla tincture mouthwash on oral aphthae: A randomized Clinical Trial


Seyyed-Amir Seyyedi, Majid Sanatkhani,Atessa Pakfetrat, Pooya Olyaee*


J Clin Exp Dent. 2014;6(5):e535-8. 


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