A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial
Hasan Hoseinpour Jajarm, Farnaz Falaki, Majid Sanatkhani, Meysam Ahmadzadeh,Farzaneh Ahrari, Hooman Shafaee *Department of Orthodontics and Dental Research Center,Faculty of Dentistry,Mashahd University of Medical Sciences,Mashahd,Iran
Abstract Recently, photodynamic therapy (PDT) has been suggested as a new
treatment option that is free from side effects for erosive-atrophic oral
lichen planus (OLP). The purpose of this study was to compare the effect of
toluidine blue mediated photodynamic therapy (TB-PDT) with local
corticosteroids on treatment of erosive-atrophic OLP. In this randomized
clinical trial, 25 patients with keratotic-atrophicerosive oral lichen planus
were allocated randomly into two groups. Group 1 (experimental): topical
application of toluidine blue with micropipette was applied, and after 10 min,
the patients were treated with a 630-nm GaAlAs laser (power density: 10 mW/cm2)
during two visits. Group 2 (control) used mouthwash diluted with dexamethasone
(tab 0/5 in 5 ml water) for 5 min, and then, it was spat out, and after 30 min,
the mouth was rinsed with 30 drops of nystatin 100,000 units for 5 min and
again spat out. Demographic data, type, and severity of the lesions and pain
were recorded before and after treatment and then at the 1-month follow-up
visit. Response rate was defined based on changes in intensity of the lesions
and pain. In the experimental and control groups, sign scores of changes
significantly reduced after treatment respectively (p=0.021) and (p=0.002), but
between the two groups, no significant difference was observed (p= 0.72). In
the experimental (p=0.005) and control groups (p= 0.001), the intensity of
lesions significantly reduced after treatment and there was a significant
difference between the two groups (p=0.001). The mean amount of improvement in
pain was significantly greater in the control group compared with the
experimental group (p<0.001) (α=0.05). Our study showed that TB-PDT with
laser was effective in the management of OLP. Keywords : Corticosteroid therapy , Photodynamic therapy , Oral lichen planus
Lasers
Med Sci,
9 December 2014 |