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جشنواره سال 1394: نفرات برتر مقاله پژوهشی آسیب شناسی دهان و فک

 نفرات برتر  مقاله پژوهشی آسیب شناسی دهان و فک

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 نفر اول مقاله پژوهشی آسیب شناسی دهان و فک


The expression of MMP-2 and Ki-67 in head and neck melanoma, and their correlation with clinic-pathologic indices


Kambiz Kamyab-Hesari, Nooshin Mohtasham, Nessa Aghazadeh, Mohsen Biglarian, Bahram Memar, *Hamideh Kadeh
*Department of Oral and Maxillofacial Pathology,School of Dentistry, Zahedan University of Medical Science,Zahedan,Iran
Abstract
Objective: Melanoma is an aggressive tumor with propensity for early metastasis and poor prognosis with delayed diagnosis. Matrix metalloproteinase2 (MMP2) is involved in degradation of extracellular matrix proteins and tumor progression. Ki67 is a predictor of tumor proliferation activity but its prognostic significance in melanoma is controversial. In this study, the prognostic value of MMP2 and Ki67 via immunostaining in head and neck melanoma is investigated.
Material and Methods: A retrospective analysis of 24 consecutive primary melanoma samples was performed. All samples were stained with monoclonal MMP2 and Ki67 antibodies. Two independent investigators evaluated the stained sections. The reactive cells were considered positive regardless of the staining intensity and reported as percentage.
Results: A strong correlation between MMP2 expression, Breslow tumor thickness, and Clark level of invasion was observed (r = 0.85, P < 0.0001 and r = 0.84, P < 0.0001, respectively). A significant positive correlation was observed between MMP2 expression and number of lymph node involved (r = 0.55, P value 0.005). MMP2 over expression (>50%) was an independent predictor of lymph node involvement (OR: 2.1, P value: 0.01). No significant association was observed between Ki67 expression and Breslow tumor thickness, Clark level, or lymph node involvement.
Conclusion: MMP2 expression correlates with tumor thickness in melanoma and is an independent predictive factor for lymph node involvement.
Key Words: Head and neck melanoma, immunohistochemistry, Ki67, MMP2

Journal of Cancer Research and Therapeutics - July-September 2014 - Volume 10 - Issue 3


نفر دوم مقاله پژوهشی آسیب شناسی دهان و فک

Expression of E-cadherin and Matrix metalloproteinase-9 in oral squamous cell carcinoma and his tologically negative surgical margins and association with clinicopathlogical parameters


Mohtasham N, Anvari K, Memar B,Saghravanian N, Ghazi N, * Bagherpour A,Ramtin M

Rom J Morphol Embryol. 2014;55(1):117-21.

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