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Spindle cell variant of ameloblastic carcinoma arising from an unicystic amelobastoma: Report of a rare case
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Venkatesh V. Kamath *   , Krishnanand Satelur , Komali Yerlagudda |
| Dr. Syamala Reddy Dental College, Hospital and Research Center, Munnekolala, Marathalli, Bangalore, India |
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Abstract: (2047 Views) |
Malignant transformation of ameloblastomas arising from an odontogenic cyst or de novo is wellrecognized. Malignancies in ameloblastomas may involve metastasis or a local dysplastic change in the tissue. The latter are classified as ameloblastic carcinomas. A 75-year-old male presented with a mandibular cystic swelling, with no evidence of metastasis. Dysplastic ameloblastic cells with spindlecell transformation were seen arising from a cystic lining with features of a unicystic ameloblastoma. Immunohistochemically the lesion stained positive with cytokeratin 8,19 and alpha smooth muscle actin, but was negative for vimentin. A diagnosis of spindle-cell ameloblastic carcinoma was made. Spindle-cell ameloblastic carcinomas are rare and this is the second case arising from a unicystic ameloblastoma reported in literature. The recognition of this transformation and inclusion of this entity in the classification of ameloblastic carcinomas is stressed.
Source: Dental Research Journal Full Text |
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| Keywords: Ameloblastic carcinoma, ameloblastoma, odontogenic carcinoma, spindle-cell transformation, unicystic ameloblastoma |
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Type of Study: case report |
Subject:
Oral and Maxillofacial Pathology
Received: 2012/11/21 | Published: 2012/01/15
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