Purpose: The aim of this study was to compare the effects of Persicamouthwash and Chlorhexidine (CHX) on colonization of Streptococcus mutans (S. mutans) on fixed orthodontic O-rings.

Materials and Method: Thirty patients with fixed orthodontic appliances and proper oral hygiene were randomly provided by CHX and Persica and trained to use these mouthwashes according to the manufacturer’s instruction. Sampling was carried out right before and 4 weeks after mouthrinsing treatment. The mean amounts of S. mutans colonies in these groups were compared. 

  Results: Comparison of S. mutans colonization within each group revealed both mouthrinses to be efficient. However, this difference was found to be significant only in CHX group.

Conclusion: Persica cannot be a good alternative mouthwash and patients on orthodontic treatment are still recommended to use CHX.