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:: دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) ::
جلد 4 شماره 4 صفحات 0-0 برگشت به فهرست نسخه ها
Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer-assisted analysis on TMA sections
چکیده:   (1918 مشاهده)

 Introduction

  Osteopontin (OPN) is non-collagenous extracellular matrix protein involved in various physiological and pathological events, including tumor progression. The aim of this study was to analyze the expression of OPN in normal oral mucosa and oral squamous cell carcinoma (OSCC) and to assess its prognostic significance.

 Methods

  The expression of OPN was immunohistochemicaly analyzed in 86 OSCC and compared with clinicopathological variable such as tumor size, nodal stage, WHO clinical stage, Ki-67 proliferation index, and patients' outcome. OPN mRNA was analyzed using quantitative real-time PCR and compared with protein OPN expression and clinical outcome in 18 OSCC samples.

 Results

  The expression of OPN protein was found in OSCC tumor cells (t-OPN) and various stromal cells (s-OPN). High level of t-OPN expression was associated with higher nodal stage (P = 0.045), higher WHO clinical stage (P = 0.033), and poor clinical outcome (P = 0.022). In multivariate analysis, t-OPN emerged as an adverse independent factor for survival (P = 0.049). Although correlated with t-OPN (P = 0.005), s-OPN was not significantly associated with clinical parameters, including patients' outcome. Also, there was no association between OPN and clinical parameters at the mRNA level.

 Conclusion

  OPN is upregulated in tumor and stromal OSCC cells. Tumor cell–derived OPN is involved in tumor progression and can independently predict the clinical outcome. Stromal-derived OPN probably has a different function compared with OPN secreted from tumor cells.


 Source: Journal of Oral Pathology & Medicine

 Full Text

واژه‌های کلیدی: osteopontin;squamous cell carcinoma of head and neck;tissue array analysis
     
نوع مطالعه: پژوهشي | موضوع مقاله: پاتولوزی دهان، فک و صورت
دریافت: 1392/8/6 | انتشار: 1390/10/25
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Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer-assisted analysis on TMA sections. 1. 1390; 4 (4)

URL: http://idai.ir/article-1-2321-fa.html



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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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