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:: دوره 3، شماره 3 - ( مجموعه مقالات بیماری های دهان 1390 ) ::
جلد 3 شماره 3 صفحات 0-0 برگشت به فهرست نسخه ها
Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications
چکیده:   (1866 مشاهده)

 Background

  This study aims to investigate the expression and significance of the αvβ6 integrin, collagen fibres and matrix metalloproteinases (MMP)-3 in oral squamous cell carcinoma (OSCC) and to analyse the possible regulatory relationships between αvβ6, collagen fibres and MMP-3.

 Materials and Methods

  A series of 80 patients (mean age 56.4 years) diagnosed with OSCC were enrolled. Associations between αvβ6, MMP-3, collagen fibre expression levels and clinicopathological parameters were evaluated using the Fisher exact test. Survival analysis was performed with Kaplan–Meier curves. Spearman rank correlation was used to analyse interactions between αvβ6, MMP-3 and collagen fibres.

 Results

  αvβ6 and MMP-3 were strongly expressed in human OSCC, especially at the peripheral borders of invasive tumour islands, and collagen fibres were generally disrupted and degraded in the same areas. The expression intensity of αvβ6 was associated with the differentiation state of cells. β6 mRNA was expressed in almost all cancer cells. In carcinomas, αvβ6 and MMP-3 expression were correlated with the distribution of collagen fibres.

 Conclusions

  Tumour cells highly expressing αvβ6 have a strong capability for invasion and migration, due to concomitant protease production and the destruction and remodelling of collagen fibres. Increased αvβ6 integrin and MMP-3 expression and collagen fibre changes in human OSCCs are related to unfavourable clinical prognostic factors and decreased survival.


 Source: Journal of Oral Pathology & Medicine

 Full Text

واژه‌های کلیدی: collagen fibre;MMP-3;oral squamous cell carcinoma;prognosis;αvβ6 integrin
     
نوع مطالعه: پژوهشي | موضوع مقاله: بیماری های دهان
دریافت: 1392/8/5 | انتشار: 1390/10/25
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Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications. 1. 1390; 3 (3)

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بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 3، شماره 3 - ( مجموعه مقالات بیماری های دهان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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