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:: دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) ::
جلد 4 شماره 4 صفحات 0-0 برگشت به فهرست نسخه ها
Utility of oral cancer diagnostic adjuncts in the adult US populations
چکیده:   (1830 مشاهده)

 Background

  Utility of diagnostic adjuncts (DAs) in an adult population with a low oral and pharyngeal cancer (OPC) prevalence is unclear. In this study, we compare the effectiveness of DAs and clinicians' conventional oral examination (COE) in detecting oral and pharyngeal cancers (OPC), in high-risk (HR) users, low-risk (LR) and alcohol, and in the overall adult US populations (GP).

 Methods

 We assumed oral cancer DAs to have 99% sensitivity and specificity. For COE, 79.6% sensitivity and 97.7% specificity were used. Using Altman's mathematical model, the positive predictive values (PPV) for a DA and COE were estimated for HR, LR, and GP groups, respectively. Three different scenarios (sensitivity constant but decreasing specificity, specificity constant but decreasing sensitivity, and decreasing both sensitivity and specificity simultaneously) were developed to simulate the true effectiveness of DAs while keeping the prevalence of OPC in HR, LR, and GP groups constant at 0.4039%, 0.0362%, and 0.1109%, respectively.

 Results

 The PPVs for a DA in HR, LR, and GP groups in the United States were estimated at 29%, 3%, and 10%, while for COE, the PPVs would be at 12%, 1%, and 4%, respectively.

 Conclusions

  Utility of DAs in LR and GP groups is negligible due to very low OPC prevalence in these populations. In HR population, DAs may have a slightly better effectiveness than clinicians only when assumed to have high sensitivity and specificity.


 Source: Journal of Oral Pathology & Medicine

 Full Text

واژه‌های کلیدی: diagnostic adjuncts;oral cancer;oral cancer prevalence;screening tests
     
نوع مطالعه: پژوهشي | موضوع مقاله: بیماری های دهان
دریافت: 1392/8/1 | انتشار: 1390/10/25
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Utility of oral cancer diagnostic adjuncts in the adult US populations. 1. 1390; 4 (4)

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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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