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:: دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) ::
جلد 1 شماره 1 و 1 صفحات 0-0 برگشت به فهرست نسخه ها
Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement
چکیده:   (1745 مشاهده)

 Objective:

  To examine changes in microvasculature and the expression of vascular endothelial growth factor A (VEGF-A) and VEGF receptor 2 (VEGFR-2) in rat hypofunctional periodontal ligament (PDL) during experimental tooth movement.

 Materials and Methods:

 Twelve-week-old male Sprague-Dawley rats were divided into normal occlusion and occlusal hypofunction groups. After a 2-week bite-raising period, rat first molar was moved mesially using a 10-gf titanium-nickel alloy closed coil spring in both groups. On days 0, 1, 2, 3, and 7 after tooth movement, histologic changes were examined by micro–computed tomography and immunohistochemistry using CD31, VEGF-A, VEGFR-2, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method.

  Results:

  Hypofunctional molars inclined more than normal molars and did not move notably after day 1 of tooth movement. Blood vessels increased on the tension side of the PDL in normal teeth. Immunoreactivities for VEGF-A and VEGFR-2 in normal teeth were greater than those in hypofunctional teeth during tooth movement. Compressive force rapidly caused apoptosis of the PDL and vascular endothelial cells in hypofunctional teeth, but not in normal teeth.

 Conclusions:

  Occlusal hypofunction induces vascular constriction through a decrease in the expression of VEGF-A and VEGFR-2, and apoptosis of the PDL and vascular cells occurs during tooth movement.


 Source: The Angel Orthodontists

 Full Text

واژه‌های کلیدی: Occlusal hypofunction، Tooth movement، VEGF، VEGFR
     
نوع مطالعه: پژوهشي | موضوع مقاله: ارتودنسی
دریافت: 1392/6/27 | انتشار: 1390/10/25
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Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement. 1. 1390; 1 (1 و 1)

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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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