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:: دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) ::
جلد 1 شماره 1 و 1 صفحات 0-0 برگشت به فهرست نسخه ها
Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice
چکیده:   (2630 مشاهده)

 Introduction

  In this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget’s disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered reveromycin A. We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget’s disease.

 Methods

 Eight-week-old male osteoprotegerin-deficient knockout and wild-type mice were injected with reveromycin A (15 mg/kg of body weight) intraperitoneally twice daily. An elastic module was inserted interproximally between the maxillary left first and second molars.

 Results

  Administration of reveromycin A to osteoprotegerin-deficient knockout mice reduced tooth movement distances, increased bone volumes at the interradicular septum, decreased osteoclast counts, and reduced serum alkaline phosphatase and tartrate resistant acid phosphatase. Reveromycin A administration also caused a temporal shift in peak Runx2 staining in osteoprotegerin-deficient knockout mice so that the overall staining time course was similar to that observed for wild-type mice.

 Conclusions

  Reveromycin A administration in osteoprotegerin-deficient knockout mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained.


 Source: American Journal of Orthodontics & Dentofacial Orthopedics

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نوع مطالعه: پژوهشي | موضوع مقاله: ارتودنسی
دریافت: 1392/6/14 | انتشار: 1390/10/25
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Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice. 1. 1390; 1 (1 و 1)

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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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