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:: دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) ::
جلد 1 شماره 1 و 1 صفحات 0-0 برگشت به فهرست نسخه ها
Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion
چکیده:   (1473 مشاهده)

 Introduction

  The purposes of this research were to investigate the long-term responses of mandibular condylar cartilage to experimentally induced disordered occlusion and to evaluate changes in the expression of the SDF-1/CXCR4 axis.

 Methods

  Experimentally induced disordered occlusions were created in 8-week-old female Sprague-Dawley rats by orthodontic methods. After 24 weeks, remodeling of the mandibular condylar cartilage was assessed by hematoxylin and eosin staining. Protein and mRNA expression of SDF-1, CXCR4, MMP9, IL6, OPG, and RANKL were investigated by means of immunohistochemical staining and real-time polymerase chain reaction.

 Results

  Obvious cartilage degenerative remodeling responses were observed they appeared as uneven distributions of cellular disposition, loss of cartilage surface integrity, and cell-free areas. Regenerative responses presenting as thickening of the whole and the calcified cartilage layers in the experimental group were also observed. Compared with the age-matched controls, the protein and mRNA levels of SDF-1, CXCR4, MMP9, IL6, and OPG, but not RANKL, were increased in the experimental group (all, P <0.05). In addition, the mRNA level of RANKL/OPG showed a decreasing trend in the experimental group compared with the age-matched controls (P = 0.052).

 Conclusions

  This study demonstrated that long-term experimentally induced disordered occlusion leads to a combined response in degeneration and regeneration of mandibular cartilage, accompanied by active interaction of the SDF-1/CXCR4 axis and local upregulation of MMP9, IL6, and OPG.


 Source: American Journal of Orthodontics & Dentofacial Orthopedics

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نوع مطالعه: پژوهشي | موضوع مقاله: ارتودنسی
دریافت: 1392/6/2 | انتشار: 1390/10/25
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Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion. 1. 1390; 1 (1 و 1)

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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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