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Hypereosinophilic syndrome – lymphocytic variant transforming into peripheral T-cell lymphoma with severe oral manifestations
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چکیده: (1201 مشاهده) |
Hypereosinophilic syndrome (HES) is a rare disease defined by organ damage directly attributable to hypereosinophilia of any type. Here, we report for the first time the case of a patient with a lymphocytic type of HES (HES-L) who had liver, skin, spleen, lung, bone marrow, digestive track, and mouth involvement. Associated T-cells displayed an aberrant CD30+ phenotype and were monoclonal. Thymus activated and regulated chemokine serum level was positive. Despite steroids (Cortancyl 20 mg [Sanofi Aventis, France], imatinib mesylate [Glivec 400 mg Novartis Europharm], interferon alpha 2A [Roferon-A 3 MUI/0.5 ml Roche]) and other lines of therapy including imatinib mesylate treatment, an oral necrotic lesion developed, and finally progressed into a peripheral CD30+ T-cell lymphoma. CHOP chemotherapy (cyclophosphamide, hydroxydoxorubicin, oncovin, prednisone), interferon-α, and mepolizumab were ineffective. Although progression into peripheral T-cell lymphoma is documented as a rare complication of HES-L, severe oral extension of HES-L is described for the first time.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Full Text |
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نوع مطالعه: پژوهشي |
موضوع مقاله:
بیماری های دهان
دریافت: 1392/5/31 | انتشار: 1390/10/25
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